Statistical methods in interphase cytogenetics: An experimental approach
نویسندگان
چکیده
منابع مشابه
Interphase cytogenetics of workers exposed to benzene.
Fluorescence in situ hybridization (FISH) is a powerful new technique that allows numerical chromosome aberrations (aneuploidy) to be detected in interphase cells. In previous studies, FISH has been used to demonstrate that the benzene metabolites hydroquinone and 1,2,4-benzenetriol induce aneuploidy of chromosomes 7 and 9 in cultures of human cells. In the present study, we used an interphase ...
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Abstract Background: Mosaic form of turner syndrome that represented by two or more cell lines in an affected individual, often has limitation for detection with classical cytogenetic methods. The present study was carried out to compare the efficiency of interphase Fluorescence In Situ Hybridisation (FISH) and cytogenetic techniques in detection of mosaic form of turner syndrome. Method...
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Short-term cultures of fifty-two samples of fibroadenomas were cytogenetically analyzed. Thirty-three of the successfully karyotyped fibroadenomas were further investigated for the presence of amplifications in the CCND1, c-MYC and HER/2-neu genes by means of FISH analysis. Compared to carcinomas, fibroadenomas seem to have less complex cytogenetic rearrangements and limited alterations on HER-...
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Specific chromosomal abnormalities such as chromosome 13 deletions and some translocations affecting the immunoglobulin heavy chain (IGH) gene, namely t(4;14)(p16;q32) and t(14;16)(q32;q23) have been associated with an adverse prognosis in multiple myeloma. Conventional cytogenetic techniques fail to detect these aberrations in the majority of cases. Thus, we have developed a novel set of inter...
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Cancer is a genetic disease caused by chromosomal aberrations and gene mutations, which propel normal cells into uncontrolled growth, invasiveness and metastases formation. Because chromosomal and genetic alterations impact tumour aggressiveness, therapy response, and prognosis their detection in clinical samples (e.g., fine needle aspirates and bioptic material) plays an increasingly critical ...
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ژورنال
عنوان ژورنال: Cytometry
سال: 1993
ISSN: 0196-4763,1097-0320
DOI: 10.1002/cyto.990140704